With the loss, Fisher falls to 2-1 in the Empire 8 Conference and 5-6 overall.
Fisher led 29-28 with 5:58 left in the first half, but Utica closed out the period with an 11-2 run to take a 39-31 lead into the locker room.
In the second half, Utica (5-6, 1-1) made its first nine shots, pushing its lead to 19 midway through the second half. The Pioneers, who won the Empire 8 title last year, missed just two shots from the floor over the first 15 minutes of the second half and shot 58% from the field for the game.
Fisher went on an 11-0 run to end the game. The Cardinals shot 46% from the floor for the game, including 55% (11-for-20) in the second half.
Stephanie Sweeney led the Cardinals with 13 points, while
Kristi Jeffres added 12 points.
Colleen Maloney, one of the nation's leading scorers and 3-point shooters, finished with a season-low nine points and shot just 1-for-8 from 3-point range.
Meghan Soja also scored nine points, while freshman Camaryn Buckner added eight points and eight boards.
Fisher will return to action at 2 p.m. on Saturday at Ithaca College.